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Additive manufacturing (AM), or 3D printing, has emerged as a transformative force in tissue engineering and regenerative medicine. This chapter explores the convergence of AM and tissue engineering, emphasizing its revolutionary impact on regenerative medicine. AM enables precise fabrication of scaffolds with tailored mechanical properties, geometries, and bio-functionalities that mimic native tissue structures. Technologies like stereolithography, extrusion-based printing, and inkjet printing offer unique benefits for scaffold creation using materials such as natural polymers, synthetic polymers, and hybrid biomaterials. AM has diverse applications in tissue engineering, including bone, cartilage, and skin regeneration. In bone tissue engineering, AM facilitates customized implants and osteoconductive scaffolds for individual patient needs. Cartilage regeneration benefits from bio-printed constructs and hydrogels that address cartilage defects, while skin tissue engineering utilizes AM to develop cell-seeded scaffolds, 3D-printed dressings, and patches for wound healing, highlighting its adaptability and potential for personalized medicine. Integrating AM with advanced biomaterials, such as bioinks and decellularized extracellular matrices, enhances scaffold bioactivity and biocompatibility, promoting cell adhesion, proliferation, and differentiation. Additionally, incorporating growth factors, genes, and cells into AM scaffolds allows precise control over tissue regeneration, while AM technologies support organ-on-a-chip platforms and patient-specific implants for personalized medical applications and drug screening. Challenges like biocompatibility, mechanical properties, vascularization, and regulatory barriers remain, but advanced techniques such as multi-material printing, vascularization strategies, 4D printing, and bioactive agents offer solutions. Future directions include new biomaterials, technological advancements, clinical translation, commercialization, and ethical considerations to further drive innovation and clinical adoption in tissue engineering.

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Advances in Additive Manufacturing in Tissue Engineering and Regeneration

  • 章节

  • 发表日期：

    2025年

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  • Shekhar V. Kokate,
  • Yogesh V. Ushir,
  • Akanksha M. Kamble,
  • Sudarshan Singh

摘要

Additive manufacturing (AM), or 3D printing, has emerged as a transformative force in tissue engineering and regenerative medicine. This chapter explores the convergence of AM and tissue engineering, emphasizing its revolutionary impact on regenerative medicine. AM enables precise fabrication of scaffolds with tailored mechanical properties, geometries, and bio-functionalities that mimic native tissue structures. Technologies like stereolithography, extrusion-based printing, and inkjet printing offer unique benefits for scaffold creation using materials such as natural polymers, synthetic polymers, and hybrid biomaterials. AM has diverse applications in tissue engineering, including bone, cartilage, and skin regeneration. In bone tissue engineering, AM facilitates customized implants and osteoconductive scaffolds for individual patient needs. Cartilage regeneration benefits from bio-printed constructs and hydrogels that address cartilage defects, while skin tissue engineering utilizes AM to develop cell-seeded scaffolds, 3D-printed dressings, and patches for wound healing, highlighting its adaptability and potential for personalized medicine. Integrating AM with advanced biomaterials, such as bioinks and decellularized extracellular matrices, enhances scaffold bioactivity and biocompatibility, promoting cell adhesion, proliferation, and differentiation. Additionally, incorporating growth factors, genes, and cells into AM scaffolds allows precise control over tissue regeneration, while AM technologies support organ-on-a-chip platforms and patient-specific implants for personalized medical applications and drug screening. Challenges like biocompatibility, mechanical properties, vascularization, and regulatory barriers remain, but advanced techniques such as multi-material printing, vascularization strategies, 4D printing, and bioactive agents offer solutions. Future directions include new biomaterials, technological advancements, clinical translation, commercialization, and ethical considerations to further drive innovation and clinical adoption in tissue engineering.