This chapter examines the complex relationship between suicidal behavior and personality disorders, highlighting behavioral dysregulation, impulsivity, emotional instability, and interpersonal difficulties as key contributors to suicidality. While traits such as impulsivity and aggression are shared across various mental health conditions, they manifest distinctively in personality disorders, particularly borderline personality disorder. The chapter explores suicidal behavior through modern classification systems, focusing on the Alternative Model for Personality Disorders (AMPD), which adopts a dimensional approach centered on personality traits and functional impairments. The AMPD’s emphasis on impaired self- and interpersonal functioning aligns with key psychological mechanisms associated with suicidality, including defeat, entrapment, and emotional dysregulation, providing valuable insights for both research and clinical practice. The chapter advocates for integrating contemporary suicidal behavior models into the AMPD framework to enhance the understanding of how suicidal behaviors develop and persist in individuals with personality disorders. Cultural variability in the expression of personality disorders and their relationship to suicidality are also explored, underscoring the importance of culturally sensitive interventions.