Mental health disparities among immigrant populations is an understudied issue in France, despite growing evidence linking discrimination to adverse psychological outcomes. This study explores the impact of origin-based discrimination on mental health among immigrants in France, addressing a significant gap in the literature. Drawing on data from the “Trajectories and Origins 2” (TeO2) survey, conducted by INSEE and INED, the analysis examines self-reported depression symptoms in relation to three key independent variables: origin-based discrimination, being target of racist insults, and affiliation with a discriminated group. Descriptive results reveal significant patterns such that immigrants who reported experiences of discrimination consistently exhibit higher rates of self-reported depression symptoms compared to those who do not. The rates of depression symptoms are particularly elevated among immigrant women who have been exposed to some form of discrimination. By focusing on the French context, this study provides evidence on the mental health inequalities faced by immigrants, complementing existing research from other European nations and the U.S.