Short bowel syndrome (SBS) is a rare malabsorptive disorder, most commonly resulting from extensive surgical resection of the small intestine. It is linked to considerable morbidity and mortality, diminished quality of life, and substantial healthcare costs. Over the past five decades, the management of patients with short bowel syndrome (SBS) has significantly advanced. Parenteral nutrition (PN) has become the standard of care, with various formulations available for inpatient and outpatient settings. However, PN remains associated with substantial complications, including infection risk, catheter-related malfunctions, thrombosis, and metabolic disturbances. It also increases healthcare costs and negatively impacts quality of life.