Short bowel syndrome (SBS) is a complex condition characterized by significant malabsorption following extensive intestinal resection or dysfunction. Effective management requires a multidisciplinary team involving gastroenterologists, surgeons, anesthesiologists, intensivists, dietitians, and transplant specialists. This chapter outlines the coordinated roles of each discipline across various stages of SBS, from initial diagnosis and conservative management to surgical intervention and long-term rehabilitation. Emphasis is placed on the importance of intestinal adaptation, nutritional optimization, the application of enhanced recovery protocols, and criteria for intestinal transplantation. Surgical options, including bowel-lengthening procedures, such as LILT, STEP, and SILT, are reviewed in detail with guidance on patient selection. Through a collaborative, patient-centered approach, clinicians can improve survival, reduce parenteral nutrition dependence, and enhance quality of life for individuals with SBS.