The chapter explores the social mobilization of families of the disappeared in Mexico in a context of systemic violence. The existing literature addresses the mobilization of the families from a contentious politics and network-theory perspective at the national level. Yet, the ways in which the families of the disappeared have made connections abroad with institutions and civil society organizations (CSOs) continue to be understudied. The chapter argues that the mobilization of the families of the disappeared, particularly in the deployment of domestic and international institutions and mechanisms, is not about covering larger political scales, as it is often argued in the transnationalism literature, but rather about connecting local spaces. The families of the disappeared continue creating links between localities with civil society organizations within Mexico and across the North American region while framing human rights violations in general and disappearances in particular as a North American issue.