This chapter focuses on self-management and patient education interventions for individuals with rheumatic diseases. It emphasizes the importance of these interventions in helping patients effectively manage their chronic conditions, reduce symptoms, and improve overall quality of life. The chapter highlights various studies that support the value of self-management interventions, including those addressing inflammatory arthritis and persistent musculoskeletal disorders. Additionally, it explores the role of self-efficacy in managing chronic diseases and emphasizes the significance of health literacy in achieving positive health outcomes. The chapter provides practical tips for healthcare providers to promote health literacy and communication, such as using interactive tools like “Ask-Tell-Ask” and “Ask Me 3®.” It also underscores the benefits of support and education programs in addressing psychosocial barriers and enhancing patient compliance. The chapter concludes by presenting best practice examples, including the LupusLine® program, which offers one-to-one support for individuals with lupus.