In 2021, economic losses due to supply chain disruptions in the Eurozone amounted to €112.7 billion Euro: Natural catastrophes (e.g., hurricanes, earthquakes, floods, and wildfires) multiply in the wake of climate change. The risks of pandemics, trade restrictions, cyber-attacks, and geopolitical conflicts are omnipresent. Hence, the threat of disruptive events to the European transport network grows ever greater. Additionally, GHG emissions can drastically increase by up to 50% if disruptions are not treated efficiently. Here, the project “Resilient multimodal freight transport network” (ReMuNet) comes into play: ReMuNet will enable the multimodal freight network to react and respond 20% more quickly to disruptive events and help to reduce European inland transport emissions on the main run by over 50% by 2026. As a trailblazer for the Physical Internet, the project pursues the vision to enable and incentivize synchro-modal relay-transport on European rail, road, and inland waterways to increase holistic network resilience. ReMuNet can identify and signal disruptive events and assess their impact on multimodal transport corridors. It reacts quickly to disruptive events in real time. It supports TMS providers to improve route planning resilience by communicating alternative, pre-defined, multimodal transport routes. ReMuNet orchestrates route utilization, suggests transshipment points, and optimizes capacity allocation, minimizing damage and shortening the recovery time. This paper introduces ReMuNet and its vision, objectives, and expected results.