Multiple-input multiple-output (MIMO) techniques enhance the performance of 5G beyond wireless networks. MIMO technology offers improved separation between high-gain elements and operates in multiple frequency bands. MIMO provides higher throughput, video, and other large-scale material that may travel over a network more quickly and in enormous quantities. This chapter focuses on design and analysis of MIMO antennas, which are increasingly being used in telemedicine applications to enhance communication capabilities and improve signal quality. It also provides insights into MIMO antenna design, frequency-selective surfaces for gain enhancement, and techniques to reduce side lobe levels, along with related research and simulation results. The design of a MIMO antenna for telemedicine must focus on compactness, high efficiency, and minimal interference, ensuring optimal bandwidth, gain, and isolation. MIMO reduces mutual coupling and optimizes performance through advanced design techniques, MIMO antennas play a critical role in ensuring the success of modern telemedicine systems. The MIMO antenna design proposed in this chapter may be suitable for telemedicine applications.