In the second semester of 2019–2020, I taught the Biomedical Project Development course at a university in Istanbul. I assigned the class a project whereby the students were supposed to design an ECG telemetry system. The three basic ECG leads, namely, lead I to lead III, were to be acquired, processed, and transmitted serially to a distant location. At the distant site, the ECG signals and a 1-mV test signal would be retrieved or, technically, demultiplexed from the received signal. I asked the students to use time-division multiplexing (TDM) for transmission. TDM imposes that the analog ECG signals be multiplexed in time at a rate determined by the Nyquist sampling theorem. Multiplexing is the transmission of many signals through a shared communication medium altogether. For three weeks, I explained the theory behind the project, the design alternatives, and the practical hardware issues they could face.