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The aim of this study was to formulate and monitor the stability of clindamycin hydrochloride gel used in the treatment of acne. Four formulations of clindamycin gel were prepared using the active substance clindamycin hydrochloride and clindamycin capsules 300 mg, and two gelling agents (Carbopol® 940 and Carbopol® Ultrez 10). The formulations were packed in plastic and aluminum packaging. Macroscopic analysis was performed on the prepared formulations: color, transparency and homogeneity. Also, pH value, spreadability, active substance content and stability over 3 months were determined. Formulations showed satisfactory appearance, clarity, pH value, spreadability and homogeneity. The content of clindamycin for all analyzed samples was in the satisfactory range from 94.55% to 107.41%. The developed formulations can represent reliable alternatives when it comes to galenic and magisterial preparations.

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Development and Evaluation of a Clindamycin Hydrochloride Gel Formulation for Topical Application

  • 会议论文

  • 发表日期：

    2025年

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  • Danijela Đivić Ćorić,
  • Emira Mlivo,
  • Berina Pilipović,
  • Alija Uzunović

摘要

The aim of this study was to formulate and monitor the stability of clindamycin hydrochloride gel used in the treatment of acne. Four formulations of clindamycin gel were prepared using the active substance clindamycin hydrochloride and clindamycin capsules 300 mg, and two gelling agents (Carbopol® 940 and Carbopol® Ultrez 10). The formulations were packed in plastic and aluminum packaging. Macroscopic analysis was performed on the prepared formulations: color, transparency and homogeneity. Also, pH value, spreadability, active substance content and stability over 3 months were determined. Formulations showed satisfactory appearance, clarity, pH value, spreadability and homogeneity. The content of clindamycin for all analyzed samples was in the satisfactory range from 94.55% to 107.41%. The developed formulations can represent reliable alternatives when it comes to galenic and magisterial preparations.