The paper presents the possibilities of applying some of the advanced methods of traffic safety management on multi-lane highways. This primarily refers to the application of variable speed limits on certain critical sections of the highway. The possibilities of applying a singlevariable speed limits (for all types of vehicles - freight and passenger vehicles) and for all lanes, as well as differential variable speed limits depending on the type of vehicle and a specific traffic lane, are analyzed. For these purposes, an appropriate model was developed on the VISSIM micro-simulation tool. Finally, in the final part, recommendations are given for the continuation of this research, considering future advanced technologies, such as cooperative systems in road traffic.