Test specimens of a Cr73NiMoNbTiAl nickel alloy were produced by a wire-electric discharge machining using various applied energies. The wire-electric discharge machining innovative technology opens up new opportunities for creating the structural elements and parts of complex geometric shapes for energetics and mechanical systems. At the same time, the wire-electric discharge machining produced surfaces integrity need to be improved for critical applications. Such improvement techniques should be addressed to preliminary studies developed and integrated depending on the wire-electric discharge machining mode used. In this experimental study, an advanced ultrasonic finishing by high-frequency mechanical impact treatment as a post wire-electric discharge machining processing was applied to enhance the surface quality and wear resistance of the wire-electric discharge machining fabricated nickel alloy. The work is focused on establishing a relationship between the surface morphology/roughness, composition, hardness, and residual stresses of the studied nickel alloy specimens processed by a wire-electric discharge machining applying three energetic modes and post wire-electric discharge machining processed by high-frequency mechanical impact. The wear and friction behaviors of the wire-electric discharge machining-fabricated and high-frequency mechanical impact post-processed samples were assessed and compared using multi-pass scratch tests. The results showed that the high-frequency mechanical impact treatment is effective method for improving several factors affecting the enhanced wear performance of the studied Ni-based alloy, improved surface microrelief with reduced roughness, increased hardness owing to strain hardening and compressive residual stresses.