The loss of an eye is devastating; the loss of an eye together with surrounding facial structures, doubly so. The relatively new field of anaplastology now allows the patient to be rehabilitated with a realistic orbital and facial custom-made prosthesis. This chapter provides clinical information to the oncologic ophthalmologist regarding restorative prostheses for loss of facial and orbital tissue. To help a patient fully recover and restore the quality of life after an orbital exenteration surgery, the oncologic ophthalmologist should work with a facial prosthetician (anaplastologist) from initial consultation to subsequent visits.