The Philosophy and Medicine series was conceived by H. Tristram Engelhardt, Jr. and Stuart F. Spicker in 1975 to contribute to the growing discussions of ethical and philosophical issues in the practice of medicine. Their identification of this series of problems as the focus for a book series was prescient. The ethical and philosophical issues in the practice of medicine have not diminished over time. New issues emerge and old issues need to be reconsidered. Over the last 50 years more than 150 books have been published in the series. This celebratory volume edited by the current series editors Lisa M. Rasmussen and Søren Holm looks back at the history of the series and forwards towards the new frontiers of philosophy and medicine.