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Deep brain stimulation (DBS) of the subthalamic nucleus (STN) or globus pallidus internus (GPi) is a proven therapeutic modality for Parkinson’s disease (PD) and dystonia. Many randomized clinical studies have shown an effective suppression of PD motor symptoms when stimulating either target: STN or GPi. However, incomplete understanding of the basal ganglia neuroanatomy and the therapeutic mechanisms of DBS impede personalization of this therapy and may contribute to suboptimal outcomes.

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Postmortem Dissections of Common Targets for Deep Brain Stimulation for Parkinson’s Disease, Dystonia, and Obsessive-Compulsive Disorder

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  • 发表日期：

    2025年

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  • Vanessa Milanese Holanda,
  • Erik H. Middlebrooks,
  • Natally Santiago

摘要

Deep brain stimulation (DBS) of the subthalamic nucleus (STN) or globus pallidus internus (GPi) is a proven therapeutic modality for Parkinson’s disease (PD) and dystonia. Many randomized clinical studies have shown an effective suppression of PD motor symptoms when stimulating either target: STN or GPi. However, incomplete understanding of the basal ganglia neuroanatomy and the therapeutic mechanisms of DBS impede personalization of this therapy and may contribute to suboptimal outcomes.