As your career advances, you may have opportunities to assume leadership positions in your department, academic health center/academic medical center (AHC/AMC), or university. These can include positions as a division chief, department chair, clinical/research center director, or administrative and leadership roles in your dean’s office, hospital, or university, among others. These jobs can reflect positive recognition of your skills and leadership ability and can help advance your career. However, they also can consume significant time and effort and distract you from other career priorities. You should carefully consider how the opportunity for a leadership position fits into your overall career goals and if you have a passion for administration and leading others. You can position yourself for success in these positions by developing your leadership skills through both experiential learning and formal training. When the opportunity to assume a leadership role arises, you should carefully consider the advantages and disadvantages, thoroughly understand the responsibilities and the available resources, and evaluate the potential impact on your other career goals and priorities as well as your personal life. A common mistake to avoid is agreeing to assume additional administrative responsibilities without planning to reduce your efforts in other areas to compensate for the time and expectations of the additional role. Advice from mentors, coaches, trusted peers, and family can all provide useful insights to help you decide if and when a leadership role might be right for you.