Change is inevitable, especially at academic institutions whose mission involves creating and disseminating new information, knowledge, and technology. For medical school faculty, change can bring new opportunities, intellectual stimulation, and renewed career satisfaction. But it often can also cause uncertainty and disruption that may be difficult to handle. Anticipating and being prepared for potential changes can help you take positive advantage of the possibilities they may afford and help you avoid the problems they may create. Common institutional changes that can impact your career include shifts in funding and prioritiesPriorities, the appointment of new leaders, and alterations in policies and practices, any of which can affect your work, expectations, and personal prioritiesPriorities. Trying to understand the reasons for institutional changes can help you find the most beneficial way to adapt. However, when institutional changes are deleterious, being able to objectively demonstrate their impact on you and your program is the best way to have them modified or even withdrawn. Adapting to subjective changes in organizational and societal culture requires an understanding of expectations, sensitivities, and terminology, which can be particularly difficult because of the wide variations that normally occur within academic health centers/academic medical centers (AHCs/AMCs) and the local community. Adapting to changes in your personal prioritiesPriorities should include careful self-reflection and interaction with your department and institution leaders to ensure alignment of everyone’s expectations.