Faculty members interact frequently and often work closely together; collaborative opportunities and collegiality are major assets for academic medicine. Nevertheless, it is not surprising that disagreements and even conflicts may occur between faculty. Knowing how and when to deal with uncooperative or challenging colleagues is important to your welfare and success. Conflicts with colleagues may be especially difficult to manage since you will likely need to continue to work together, and, unfortunately, the colleague may have the ability to adversely impact your reputation. Many conflicts can be handled by improved communication and understanding. For particularly challenging cases, it may be advisable to involve an impartial, third-partyThird-party departmental leader, senior faculty member, or ombudspersonOmbudsperson to help resolve the problem. Most schools have an office of faculty affairsFaculty affairs, office that may provide mediators. If the faculty member with whom you are having difficulties is someone to whom you report (e.g., your division chief, your department chair) the situation becomes even more complex, and you may need to seek assistance from offices above that individual. Documentation of the difficulties and the steps taken for resolution are essential.