Background-Aim: the aim of this study is to present guidelines for the management of rectus diastasis. In addition to presenting a variation of the surgical technique for the treatment of diastasis recti with the addition of muscle regeneration by transformed monocytes, namely ‘Muscle Regeneration and Abdominal Lift Technique’ (MURAL-T). Methods: From May 2020 to December 2024, 150 postpartum women between 35 and 65 were operated for DRA only with the personal muralt technique. All patients followed a pre-operative approach to treating dysbiosis and regulating intestinal transit. In 50% of cases they underwent a weight loss program to reduce intra-abdominal pressure. All patients followed a post-operative rehabilitation protocol of the abdominal core and pelvic floor from the 20th post-operative day. Results: The maximal intra-rectal width (as calculated by CT scan) of the 50 women allocated to Group I decreased from 46 mm to 3 mm after 3 months (P < 0.001); in the 50 women allocated to Group II the maximal intra-rectal width decreased from of 65 mm to 1.1 mm three months after the intervention (P < 0.001), while in the remaining 50 women of Group III (MuralT + monocyte injection), it decreased from 49 mm to 0 mm. In the group III, who received also the monocyte injection, mean rectal thickness was 12.8 mm at baseline and increased to 17.1 mm after 3 months (P < 0.001). Complications: Occurred in 3 patients (5%) and were related to aesthetic issues. Conclusion: the Mural-T program treats the diastasi recti using a multidisciplinary team that uses combined methods with produced good results in terms of functional, aesthetical, morphological outcomes, and quality of life.