The aim of this chapter is not to provide a mere description of facial and neck anatomy, as such information are readily available and surely better addressed in any human anatomy text. Instead, this chapter will present a “practical” anatomy, focusing not just on anatomical structures, such as nerves, blood vessels, muscles, etc., but on those anatomical relationships between them, that represents the cornerstone in the field of surgical facelift procedures. In the following text, the reader will find an anatomical overview of the different structures that has implications for the scope of this book, followed by a deep focus on the layers of the face and neck. Understanding facial and neck architecture, represented by fascial anatomy, is the essential ground to build any expertise in the field of surgical facelift.