This research aims to study and identify factors affecting student satisfaction with HyFlex learning management in the Faculty of Science and Technology at Suan Sunandha Rajabhat University. This is done by creating and testing a confirmatory factor analysis model for factors influencing satisfaction with HyFlex learning management. The study evaluates the component weights and relationships between various factors and satisfaction with HyFlex learning management. It presents empirical evidence and recommendations for enhancing the efficiency and satisfaction of HyFlex learning through model analysis using AMOS software. The research results indicate that the model obtained from the CFA analysis is well to excellently consistent with the empirical data, meeting the criteria for assessing model fit according to various indices. Therefore, this model can be appropriately interpreted and used to explain the factors influencing satisfaction with HyFlex learning management. The study concludes that the critical variables demonstrating satisfaction with HyFlex learning management are assessment, teaching content, teaching ability, learner-instructor interaction, and learning facilities, all of which are statistically highly significant. Meanwhile, helping reduce student expenses is a statistically significant factor. Furthermore, the research results can lead to policy formulation and guidelines for developing HyFlex learning management in educational institutions.