The drought in 2018 and 2022 in The Netherlands caused a reverse modal shift from inland waterways to road transportation within the Twente region in the eastern part of the country. These drought periods resulted in delivery delays, disruption of planning and operational processes, and reduced production capacity, affecting the entire logistics ecosystem in the region, consisting of inland ports and container terminals, logistic and production companies using the ports, and policymakers. As a result, these stakeholders are looking for solutions that increase the resilience of operations in the Twente corridor, helping them prepare, react, recover, and learn from disruptions. To improve the resilience, a digital twin is being developed to monitor the corridor’s activities, performance, and infrastructure in real-time, providing alerts and useful information in the face of disruptions. This paper reports the results of the requirements analysis for the development of the digital twin, including the validation and prioritization by involved stakeholders. Although the research focuses on the Twente region, the program of requirements can be reused as a starting point for other multimodal corridors that face similar challenges and disruptions.