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Cardiovascular diseases are the greatest cause of death worldwide. Antiarrhythmic drugs are widely used in the treatment of these diseases, however the study of their action in the organism is complex. The development of softwares contributes to faster decision making and prediction of the pharmacological effects of the tested drugs. PharmaLab is a software developed to predict the effects of antiarrhythmics in ventricular cardiomyocytes of mice and was used in this Scientific Initiation Project to simulate the effects of Naringin (IC = 508,5 µM for ICaL), a flavonoid extracted from citric plants and Chinese herbs. The parameters used for the simulations were Duration of Pulse 100000 ms, Pulse Width 1 ms, Stimulation Frequency 0.5 Hz, Stimulus Current 80 pA/pF, Pulse Train Application Time 1000 ms, Initial Sarcomere Length 2.1 µm and Cell Length 100 µm, applied for the concentrations 100, 200. 400 and 800 µM. After the simulations it was obtained an action potential like the one of the original experiments for the concentration of 800 µM. The software also provided a fitting value of APD90 for the same concentration, although the simulated APD50 was off by 1.13%. Alongside, it was generated data regarding the percentual inhibition of ICaL current for the said concentrations, showing again similarities between the simulation and the experiment.

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Registration and Simulation of the Antiarrhythmic Effects of Naringin By Use of the Software PharmaLab

  • 会议论文

  • 发表日期：

    2025年

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  • Guilherme Gadelha da Silva,
  • M. M. Grillo,
  • M. L. A. Camargo,
  • D. G. Goroso,
  • J. L. Puglisi,
  • R. R. Silva

摘要

Cardiovascular diseases are the greatest cause of death worldwide. Antiarrhythmic drugs are widely used in the treatment of these diseases, however the study of their action in the organism is complex. The development of softwares contributes to faster decision making and prediction of the pharmacological effects of the tested drugs. PharmaLab is a software developed to predict the effects of antiarrhythmics in ventricular cardiomyocytes of mice and was used in this Scientific Initiation Project to simulate the effects of Naringin (IC = 508,5 µM for ICaL), a flavonoid extracted from citric plants and Chinese herbs. The parameters used for the simulations were Duration of Pulse 100000 ms, Pulse Width 1 ms, Stimulation Frequency 0.5 Hz, Stimulus Current 80 pA/pF, Pulse Train Application Time 1000 ms, Initial Sarcomere Length 2.1 µm and Cell Length 100 µm, applied for the concentrations 100, 200. 400 and 800 µM. After the simulations it was obtained an action potential like the one of the original experiments for the concentration of 800 µM. The software also provided a fitting value of APD90 for the same concentration, although the simulated APD50 was off by 1.13%. Alongside, it was generated data regarding the percentual inhibition of ICaL current for the said concentrations, showing again similarities between the simulation and the experiment.