Data issues arise at critical points in university–industry (UI) interactions. Issues arising at early stages may require a formal agreement with disclosure and confidentiality terms. As the depth of involvement and collaboration increases, issues to be discussed and resolved also include access to, generation of, intended use, potential value, sharing, and regulation of data. This chapter provides an overview of key issues, policies, and regulations in data management, providing guidance as to how they might be resolved in UI research agreements. As described in the chapter, data issues should be considered from at least four perspectives: privacy, regulation, security, and value. In UI agreements involving generation, use, or transfer of data, the term “Data” should be clearly defined. Related terms regarding data in deliverables and rights and obligations of the parties should be discussed and then described in enough detail for the parties to understand how to comply with the terms.