Cold gas dynamic spraying technology is an emerging low-temperature surface solid deposition technology, which is often used to repair defects on the surface of parts and improve the performance of coating surfaces. The key to studying the deposition of multi-particle different powder materials on the substrate by numerical simulation is to study the deposition coating. This work uses numerical simulation to explore the deposition of various powder particle materials on the Al6061 substrate; firstly, the Al2O3 and Al6061 multi-particle models are realized by Python programming code. The multi-powder particle material model is nested in the Coupled Eulerian-Lagrangian (CEL) deposition model to simulate the compaction of Al2O3 on the Al6061 coating, so as to control the porosity of the coating; for the first time, Python programming code is combined with CEL method to simulate the numerical simulation of the deposition of various powder particle materials on the substrate. The research results show that the porosity value of Al6061 coating compacted by Al2O3 powder particle group is 1.175%, and the porosity value of Al6061 coating that has not been compacted is 1.91875%. Al2O3 powder particles can effectively control the porosity of Al6061 coating; the Al2O3 powder particles have a shot peening effect during the compaction of the coating. This method provides a new idea for simulating the deposition of various powder particle materials on substrates.