Progressive supranuclear palsy (PSP) is a neurodegenerative disorder that usually begins around age 60 with symptoms such as imbalance, difficulty swallowing or pronouncing words, and urinary incontinence. Early in the disease, it may resemble Parkinson’s disease. Specific findings on physical examination may help distinguish this from other forms of parkinsonism. In some cases, the diagnosis may be more clear from brain imaging studies or ocular motor studies. PSP is usually managed by a movement disorders specialist. There is no known treatment. The disease is usually fatal in 5–10 years from symptom onset.