CANVAS results from a genetic mutation and causes gradually progressive unsteadiness usually beginning around age 60 (though the age range is broad, ranging from 30s to 70s). Symptoms include unsteadiness, clumsiness, and reduced touch sensation. In order to distinguish this from similarly appearing diseases, it is often helpful to check several otovestibular tests, brain imaging and electromyography, and nerve conduction velocities. If the results of that workup are compatible with CANVAS, then genetic testing may help confirm the diagnosis. There is no effective treatment, though many patients will try vestibular rehabilitation therapy.

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CANVAS

  • Marcello Cherchi

摘要

CANVAS results from a genetic mutation and causes gradually progressive unsteadiness usually beginning around age 60 (though the age range is broad, ranging from 30s to 70s). Symptoms include unsteadiness, clumsiness, and reduced touch sensation. In order to distinguish this from similarly appearing diseases, it is often helpful to check several otovestibular tests, brain imaging and electromyography, and nerve conduction velocities. If the results of that workup are compatible with CANVAS, then genetic testing may help confirm the diagnosis. There is no effective treatment, though many patients will try vestibular rehabilitation therapy.