This chapter addresses addictive behaviors, stigma, and gender from an anthroposociological lens. Addictive behaviors and dependencies have been the subject of intense debate in the social sciences. However, the discussion regarding the analysis of the impact of stigma associated with these conditions has been scarce, especially when considering the gender dimension. This reflection aims to address these intersections and contribute to a broader view on the subject, based on the latest data published in the European Drug Report (EUDA, European drug report 2024: Trends and developments. https://www.euda.europa.eu/publications/european-drug-report/2024_en , 2024), as well as data produced by the official Portuguese entity, the Institute for Addictive Behaviors and Dependencies, I.P. (ICAD, 2023). The decriminalization policy adopted in Portugal in 2001 appears to facilitate the reduction of stigma and encourage treatment. However, the data suggest that social structure and gender stereotypes still influence consumption patterns. In this sense, we understand that social and health interventions need to be culturally sensitive and attentive to differences in men’s and women’s paths regarding consumption and treatment, which demonstrates the ongoing importance of adapting social policies to dynamic contexts, considering not only public health norms but also the social and cultural constructions that shape addictive behaviors.