This chapter addresses the stigma experienced by some women who use alcohol in an Indigenous community in central Mexico. It analyzes the implications of being labeled as users of alcohol in a community with beliefs and values that accept and privilege men’s alcohol use, but disapprove and condemn its use by women. This stigmatization of women by their own community does not prevent them from using alcohol, but it has negative consequences. The second part of the chapter presents testimony of two women from an Indigenous community in the state of Hidalgo. These testimonies reflect the context, beliefs, customs, consequences, and cultural practices associated with alcohol use. Both women began to use alcohol from a very early age, and this use has significantly influenced their identity as women, as mothers, wives, and as members of the community to which they belong, perpetuating the mark of guilt, rejection, and marginalization.