Higher Education (HE), globally, is facing significant transformations due to the heavy influence of Artificial Intelligence (AI) applications within the EdTech industry. This chapter discusses the complex opportunities and challenges presented by the adoption of such technologies within the HE. It argues that, inevitably, the usage of such technologies including generative AI (such as ChatGPT), provides assurances to enhance pedagogy, student support and facilitate research activities. Despite such assurances, there are challenges with its usage, including potential biases, academic integrity and sustainability. The various measures around the globe are discussed as countries try to regulate and monitor these fast-paced technologies, depending on their socio-economic, political and cultural practices. Finally, this chapter advocates for solutions to integrate AI within the HE sector through a potential roadmap, whilst upholding ethics, equity and non-discrimination.