The chapter explores the relationship between malaria and kidney complications, highlighting how malaria, particularly severe cases caused by Plasmodium falciparum and Plasmodium vivax, can lead to acute kidney injury (AKI). The text discusses the mechanisms behind kidney damage, including immune responses, hemodynamic changes, and the role of high parasitemia. It also covers different forms of glomerulopathies linked to malaria, such as collapsing glomerulonephritis, and outlines how antimalarial drugs like primaquine may induce hemolysis, particularly in patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency, contributing to kidney injury. The importance of early diagnosis and the management of complications through supportive measures, including dialysis, is emphasized, as well as the risks associated with treatment in resource-limited settings. The chapter calls for improved strategies to manage malaria-induced kidney injury, especially in tropical areas with high disease prevalence.