This chapter seeks to discuss the distinct movements of desire, which culminate in different desiring circuits and modes of subjectivation; in other words, it works on the relationship between desire and its different machines. It maps the three hegemonic political machines that act on desire: State codification, neoliberal and neofascist. And in the interventive sphere, it presents the production–reproduction–antiproduction klinic, created by Baremblitt, which is a device that seeks to performatize these different circuits of desire at stake, with the aim of promoting processes of reconfiguration of the relations of forces and desires, the autonomy and the empowerment of social minorities.