This chapter provides a scoping review of prior studies on macro-social level influences on loneliness and aims to highlight existing research gaps. Several studies have so far focused on concrete macro-level characteristics to explain variations in loneliness prevalence. Macro-social level influences identified so far include sociodemographic composition, social wealth and welfare regime, generalized trust, norms of family obligations, social interactions, internet access, and a good opportunity structure for societal participation. Our understanding of the mechanisms linking macro-level conditions to loneliness is, however, limited. Explanations are often post-hoc and not guided by strong theoretical expectations. Studies often employed diverse proxies to represent macro societal-level characteristics. The correlation between macro-societal characteristics as well as the interaction between them is often not considered. In addition, several other macro-level characteristics like decreasing fertility rates, increases in migration flows, residential design and built environment policies may also significantly impact loneliness but have so far not been thoroughly considered. This chapter employs a systematic review of literature on macro factors to create a comprehensive picture of current research evidence, to assess the quality of this evidence and to examine the strength of research findings, while also pointing to possible directions of future studies.