Research on the influence of structural factors on loneliness is only beginning to gain ground. In this paper, we aim to better understand the cross-country differences in loneliness by testing the potential role of selected relevant macro factors wealth, digitalization, individualism, political trust, and community circumstances for loneliness in later life in European countries. We employ a fuzzy-set Qualitative Comparative Analysis (fsQCA) to examine configurations of conditions that result in low levels of loneliness at the country level. Data come from the EQLS 2016 survey and Eurostat. Results revealed that wealth is a necessary condition for low loneliness. Furthermore, three distinct pathways to reduced loneliness emerged: (1) “Trusting societies,” characterized by high digitalization and high political trust; (2) “Individualistic societies,” delineated by high levels of digitalization and individualism; and (3) “Communal ties societies,” defined by low individualism and high community safety. The first two pathways are potentially alternative to each other, while the third is unique. Economic, cultural, and social factors at macro level are closely linked together in influencing loneliness in later life in European countries.