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High-performance liquid chromatography (HPLC) is a cornerstone of analytical chemistry, particularly pharmaceutical analysis and disease monitoring. This book chapter underscores the adaptability of HPLC in biomedical, forensic, environmental, and pharmaceutical domains, reassuring the readers about its robustness and versatility. It also highlights the significance of HPLC in handling complex sample matrices, emphasizing its integration with advanced sample preparation techniques like SPE, LLE, QuEChERS, and DLLME. Moreover, the method’s utility in biomarker identification, therapeutic monitoring, and environmental safety illustrates its pivotal role in modern scientific research. This article compiles and provides a comprehensive perspective on HPLC’s evolving capabilities in addressing analytical challenges by exploring advancements in derivatization, automation, and coupling with mass spectrometry.

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Advancements in High-Performance Liquid Chromatography: Transforming Analytical Chemistry Across Biomedical, Pharmaceutical, and Environmental Domains

  • 章节

  • 发表日期：

    2025年

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  • Vivek Singh,
  • Mohammad Kashif,
  • Saba Ubaid,
  • Tanvi Singh,
  • Roma Pahwa,
  • Abhishek Kumar Singh,
  • Anand Singh

摘要

High-performance liquid chromatography (HPLC) is a cornerstone of analytical chemistry, particularly pharmaceutical analysis and disease monitoring. This book chapter underscores the adaptability of HPLC in biomedical, forensic, environmental, and pharmaceutical domains, reassuring the readers about its robustness and versatility. It also highlights the significance of HPLC in handling complex sample matrices, emphasizing its integration with advanced sample preparation techniques like SPE, LLE, QuEChERS, and DLLME. Moreover, the method’s utility in biomarker identification, therapeutic monitoring, and environmental safety illustrates its pivotal role in modern scientific research. This article compiles and provides a comprehensive perspective on HPLC’s evolving capabilities in addressing analytical challenges by exploring advancements in derivatization, automation, and coupling with mass spectrometry.