This chapter defines fecal incontinence and other types of bowel incontinence. The impact of fecal incontinence on quality of life using evidence from qualitative research studies is summarized. The life experience of men and women with fecal incontinence is summarized. Six domains of quality of life when living with fecal incontinence were synthesized from evidence in the literature and organized into a framework. These domains are living with fecal incontinence related to: (i) relationships and role, (ii) time and planning, (iii) self-esteem, body image and bodily symptoms, (iv) sexuality, (v) dietary issues, and (vi) barriers and facilitators of seeking treatment and self-management support. Key points from each domain are highlighted in this chapter. Implications for advanced practice continence nurses managing fecal incontinence are explained.