This chapter illustrates the adoption of the protocol presented in detail in the previous chapter applied to a variety of cases, which include the correction of dentofacial deformities of II and III class, as well as asymmetries. The discussion focuses on orthognathic surgery as unique treatment, whereas the combination of orthognathic surgery with temporomandibular joint procedures, including proportional condylectomy and alloplastic joint replacement, will be comprehensively analyzed in the next chapter. This chapter will develop both a section of clinical analysis where the most important parameters for dentofacial correction are evaluated and the most appropriate skeletal movements established in VSP. As stated in the previous chapter, yet corroborated by a robust body of literature evidences, such movements in orthognathic surgery are largely based on personal experience and esthetic taste; thus, although there might be a general agreement, proposed movements might vary between different surgeons. The core idea of this chapter is to relate clinical analysis, which can consistently change depending on the reference models and cephalometric analyses, with the appropriate corrective actions in VSP, to demonstrate versatility of orthognathic surgery software for the simulation of every clinical scenario.