In this chapter, the author describes his meeting with Rita Levi-Montalcini, an Italian-Jewish neurobiologist who overcame astonishing odds during World War II. Most recently, the author was one of the organizers of an international meeting in Rome celebrating Rita’s 100th birthday and was also with her for her 101st, 102nd, and 103rd birthdays. Rita made history by becoming the first Nobel laureate to reach 100 years of age, embodying resilience and a dedication to science. Here, the author offers a dive into Rita’s lifelong dedication to science and how her persistence and passion contributed to her successful aging.