In the digital age, digital technology represented by big data and cloud computing brings about changes in transaction methods, meets diversified consumer needs, accelerates the transformation of cross-border trade and reshapes the form of international trade, and the demand for cross-border e-commerce-related talents is greatly increased. However, unlike the rapidly growing transaction volume of cross-border e-commerce, the cross-border e-commerce talents in the society fall far short of the market demand. In this regard, taking the cross-border e-commerce courses as an example, this paper briefly analyze the problems of the current teaching mode, and put forward the classroom teaching research model of “one permeation, two phases, three progressions, and four integrations” to improve the learning effect of students. Through literature analysis and data analysis, it is concluded that digital empowerment course teaching can improve students’ knowledge ability, practical ability and comprehensive ability. Finally, relevant reform measures are proposed to provide practical guidance for relevant curriculum teaching reformers.