In this chapter, we provide a comprehensive overview of the wide assortment of gene-editing tools currently available to the human stem cell field, aiming to serve as a guide for both the Parkinson’s disease (PD) research community and the broader regenerative medicine field. This chapter highlights the contributions of gene editing to PD models, to illustrate their broader applicability. While extensive literature exists on PD using model organisms and non-human cell systems, our focus is uniquely placed on human embryonic stem cells (ESCs) and human-induced pluripotent stem (iPS) cells due to their direct relevance to human etiology. We emphasize the critical role of gene editing in addressing challenges posed by genetic and phenotypic variability, demonstrating how these tools enable the creation of isogenic cell models to elucidate PD pathophysiology. Additionally, we explore the potential of advanced gene-editing solutions, including CRISPR-Cas9, base editors, prime editors, and epigenetic modulators to address diverse experimental questions with precision. We discuss how iPS cell models enhanced by programmable genetic and epigenetic modulators have been used to dissect underlying mechanisms of PD, develop regenerative medicine prototypes, and address immune compatibility challenges in cell transplantation.