The use of green chemistry techniques in the synthesis of organic compounds has generally drawn the attention of numerous researchers recently. For synthetic chemists, using green synthetic procedures and methodologies is crucial since they tend to use less hazardous and environmentally harmful materials or generate less of them. The twelve principles of green chemistry serve as a guide for chemists as they create safe chemical procedures and methods. The traditional method of synthesizing frequently involves the use of hazardous or poisonous organic solvents, catalysts, or other substances that are declared trash when the reaction is finished. New green chemistry synthesis techniques were created to lessen the use of such hazardous materials. One of these techniques is the use of microwaves to speed up the synthesis of desired molecules, produce higher-quality products with higher yields, and work in softer environments. Organic synthesis frequently uses solvent-free synthesis because it is simpler, uses fewer hazardous materials (organic solvents), and is less expensive. Solvent-free synthesis is commonly carried out in conjunction with heating, mixing, and ball milling, as well as using ultrasound and microwaves.