Climate change poses significant challenges to sustainable agriculture development in semi-arid regions, where water scarcity and temperature fluctuations are already pressing issues. Irrigation water quality plays a crucial role in maintaining soil health, crop productivity, and food security in these areas. The introduction highlights the importance of sustainable agriculture in semi-arid regions and the role of irrigation water quality in supporting this endeavor. The subsequent sections explain the impacts of climate change on water quality parameters, including temperature increase, altered precipitation patterns, salinization, and groundwater quality degradation. A comprehensive overview of strategies and solutions for maintaining and improving water quality in semi-arid areas will also be discussed. The strategies include water conservation techniques, such as efficient irrigation practices and rainwater harvesting, wastewater treatment and reuse, soil management practices to mitigate salinization and nutrient depletion and the integration of renewable energy sources into irrigation systems. The role of precision agriculture and supportive policies and institutional frameworks are also discussed. It aims to equip researchers, policymakers, and stakeholders with the knowledge and tools necessary to address the water-related challenges posed by climate change and ensure long-term food security and environmental sustainability.