The development and evolution of capsule endoscopy have revolutionised the field of gastroenterology, culminating in the emergence of colon capsule endoscopy (CCE) as a promising alternative to traditional screening methods. This paper traces the historical journey of capsule endoscopy from its inception in 2001, following FDA clearance and CE Mark certification, to its foundational roots dating back to collaborative efforts in the 1980s. Spearheaded by pioneers like Gavriel Iddan, Eitan Scapa, and Paul Swain, the innovative concept of swallowable capsules equipped with miniature transmitters and cameras has reshaped the landscape of gastrointestinal imaging. Technological advancements in capsule endoscopy have given rise to a diverse array of capsule systems, each offering unique operational features and clinical applications. Notable contenders include Medtronic’s PillCam series, CapsoVision’s CapsoCam Plus system, and emerging systems from Chinese manufacturers like Jinshan and AnX Robotica. These systems embody a spectrum of technological capabilities, from high-speed imaging to streamlined designs, poised to address distinct clinical demands and patient requirements. Amid the backdrop of the COVID-19 pandemic, disruptions in healthcare services have underscored the need for innovative solutions to ensure continuity of care. Telemedicine-enabled capsule endoscopy has emerged as a promising avenue, facilitating remote procedures and enhancing patient access while minimising exposure risks. Feasibility studies exploring the delivery of CCE directly to patients’ homes have shown promising results, suggesting a paradigm shift in CRC screening that prioritises safety, convenience, and accessibility. As healthcare systems navigate the challenges posed by the pandemic, the integration of colon capsule endoscopy and telemedicine represents a transformative approach to CRC screening. These advancements hold the potential to mitigate the long-term impact of disrupted healthcare services and ensure continuity of care for patients worldwide. Further research and validation studies are warranted to fully realise the clinical utility and efficacy of telemedicine-enabled CCE in the post-pandemic era.