Agro-production relies on mainly environmental conditions and climate change has huge impacts on agriculture particularly on water resources. Türkiye, considered as among high risk countries affected from climate change, is situated at eastern part of Mediterranean region of world. In this work, impacts of agricultural drought on agro-production of Konya Closed Basin (KCB) were assessed comprehensively and some practical solutions for productive use water resources were suggested. In result, water scarcity, becoming an increasingly serious problem in this basin day by day, has huge effects on agricultural activities. Unconscious irrigation practices result reductions in water levels. Overwater use, due to the expansion of cropped lands with high water consumption, from groundwater reservoir causes sinkholes in some part of KCB such as in Karapınar surroundings. Water use in irrigation processes is almost 75% in Konya plain and due to the severe agricultural drought in basin at recent years, it is impossible for famers to obtain economical income from agricultural activities without irrigation even from winter cereals. Development of drought-resistant plant species and widening of their cultivation is one of the important solutions for mitigating adverse effects of drought on water resources. In addition, reducing planting areas with high water consuming crops such as corn or in the other word increasing planting areas of less water consuming crops is another viable solution for sustainable agricultural water management in semi-arid KCB. Deficit irrigation is another important strategy for achievement better water productivity with application of unit water especially in water shortage ecologies. As a result, climate change is reality and agro-production program must be done by considering current water resources in water-starved areas.