Nanosafety has become a pivotal area of study amidst the rapid advancements in nanotechnology. Nanomaterials (NMs), defined by their nanoscale dimensions, exhibit unique properties that enable diverse applications across industries, including electronics, medicine, and consumer goods. However, these properties also raise significant health and environmental concerns. Nanosafety encompasses the investigation and management of risks linked to the lifecycle of NMs—from production to disposal. As NMs interact with biological systems, they can present altered toxicological profiles, prompting concerns over their cytotoxicity, immunotoxicity, and genotoxicity. Additionally, understanding the environmental behavior of NMs, such as their transport and potential for bioaccumulation, is essential for assessing their ecological impact. A multidisciplinary approach, integrating toxicology, materials science, and computational modeling, is crucial for developing robust risk assessment frameworks.