The galvanic skin response (GSR) measurement is related to checking changes in the electrical properties of the skin and can be used to measure sudomotor activity. The functionality of the GSR is connected to the sweat glands, whose electric resistance decreases with its filling. With this, activities involving the sympathetic nervous system can be monitored. Discomfort and other feelings, such as levels of stress in individuals, can be measured. In this context, this work presents the development of a low-cost circuit to realize the acquisition of GSR. The circuit comprises a third-order low-pass filter and a current source connected to electrodes placed on the subject’s skin. The validation of the system involved three tests. The first test was related to the frequency response of the developed sensor. The second test was realized to verify ranges of resistance that the system can measure (test made with a range of resistances). The last test was the application of the system over a volunteer during a blood pressure measurement to ensure the system’s functionality in real applications. The final PCB presented a total cost of $7.53 (Dollar - 04/2024), a linear response (R \(^{2}\) = 0.999), and was capable of identifying and quantifying the variance of the skin during the blood pressure measurement.