Scholarlink

Spinal cord injury (SCI) is a terrible condition that can affect humans. It is characterized by the interruption of the neurological signal, affecting sensorimotor functions, with social and psychological losses and high treatment costs. There is still no cure for SCI, encouraging research for new therapeutic approaches. In this context, Photobiomodulation (PBM) has shown promising results regarding the inflammatory, pain, immunological, and antifibrotic response, favoring the healing process in several tissues. Objective: To evaluate the motor function in rats treated with PBM after SCI by hemisection using quantitative movement analysis techniques. Methodology: 15 male rats were distributed in three groups: Control (C), Injury (I), and Photobiomodulation (PBM, continuous wave, 780 nm). Groups I and PBM were submitted to SCI between T9/T10, by hemisection of the spinal cord. The Sciatic Functional Index (SFI) and average speed were evaluated by kinematic analysis of the gait of these animals for 28 days, with 7-day intervals. Results: The PBM group showed a significant increase in the average speed at 7, 14, and 21 experimental day times evaluated and improvement in SFI. Conclusion: The kinematic and thesciatic functional index analysis are reliable evaluating tools for motor function in rats treated with PBM after SCI, showing increased gait speed and range of motion improvement on the 14th and 21st-day post-SCI.

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Biomechanical Analysis of Experimental Spinal Cord Injury Treated with Photobiomodulation

  • 会议论文

  • 发表日期：

    2025年

查看全文
  • Luis Filipe Karatanasov Beloni,
  • Leonardo Borges Lima,
  • Marcele Florencio Neves,
  • Mario Oliveira Lima,
  • Fernanda Pupio Silva Lima,
  • Rodrigo Alvaro Brandão Lopes-Martins,
  • Luciana Barros Sant’Anna,
  • Emilia Angela Lo Schiavo Arisawa

摘要

Spinal cord injury (SCI) is a terrible condition that can affect humans. It is characterized by the interruption of the neurological signal, affecting sensorimotor functions, with social and psychological losses and high treatment costs. There is still no cure for SCI, encouraging research for new therapeutic approaches. In this context, Photobiomodulation (PBM) has shown promising results regarding the inflammatory, pain, immunological, and antifibrotic response, favoring the healing process in several tissues. Objective: To evaluate the motor function in rats treated with PBM after SCI by hemisection using quantitative movement analysis techniques. Methodology: 15 male rats were distributed in three groups: Control (C), Injury (I), and Photobiomodulation (PBM, continuous wave, 780 nm). Groups I and PBM were submitted to SCI between T9/T10, by hemisection of the spinal cord. The Sciatic Functional Index (SFI) and average speed were evaluated by kinematic analysis of the gait of these animals for 28 days, with 7-day intervals. Results: The PBM group showed a significant increase in the average speed at 7, 14, and 21 experimental day times evaluated and improvement in SFI. Conclusion: The kinematic and thesciatic functional index analysis are reliable evaluating tools for motor function in rats treated with PBM after SCI, showing increased gait speed and range of motion improvement on the 14th and 21st-day post-SCI.