Pharmacogenomics is a science studying how genetic variations influence drug efficacy and potential adverse effects. These variations may involve metabolic enzyme activities or HLA markers that increase the risk of specific adverse drug reactions. Identifying these genetic factors can aid clinicians in selecting appropriate drugs and doses. Although certain pharmacogenomic tests are approved by the FDA, not all are covered by insurance. Therefore, clinicians must understand both the benefits and limitations of these tests to effectively use them in clinical decision-making. This chapter includes a list of resources detailing drug-gene associations, along with FDA-approved pharmacogenomic biomarkers for dermatologic drugs, and their clinical indications.