Cloud computing is a model that enables on-demand access to computing resources hosted by third-party providers. It presents promising opportunities for Saudi private hospitals as they strive to deliver high-quality healthcare services, meet a large share of the country’s healthcare market demands, and achieve substantial financial returns. However, despite its strategic potential, Saudi private hospitals continue to lag behind in adoption. Consequently, this research employs quantitative and qualitative methods guided by the ACC-PH framework to explore the factors influencing cloud adoption. A quantitative study involving surveys of 650 decision-makers and employees confirmed the positive impact of technological factors (security, compatibility, reliability, and relative advantage), organisational factors (attitude toward change, top management support, prior experience, organisational readiness, and cost analysis), and environmental factors (Internet connection, competitive pressure, and cloud providers), while rules and regulations showed no significant influence. An initial qualitative study involved semi-structured interviews with twelve decision-makers, which validated the significance of all factors, but highlighted challenges related to security, compatibility, organisational readiness, and Internet connection. A subsequent qualitative study involving seven decision-makers provided contextual evidence and justifications for these findings, offering valuable insights. Thus, this research makes a unique contribution by developing a detailed roadmap tailored to each factor that influences cloud adoption. The roadmap aims to support decision-makers in Saudi private hospitals in adopting cloud computing to reduce costs and optimise healthcare services for a significant portion of the country’s population.